drug-drug interaction blog posts

04 October, 2017

Shining the light on drug-drug interactions (DDI)

By Guy Webber

Advancements in in vitro technologies and analytical instrumentation over the past decade allows scientists to apply a variety of in vitro based assays designed to rapidly assess risk-liability, such as drug-drug interactions (DDI), one of the factors contributing to both current high attrition rates and delays in development.

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04 October, 2017

How in vitro assays and drug metabolism are being used to de-risk drug development

By Guy Webber

If all molecules in discovery and development were added together over recent years and compared to the number of successful drug approvals each year, the ratio is (approximately) 10,000:1. In other words, for every 10,000 molecules entering drug discovery, 9,999 will fail during some stage of the development process. Evidently, developing a molecule that has a desired, efficacious yet safe effect in humans is a remarkable achievement considering the lengthy, complex and expensive process.

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