It is well established that personalized medicine can overcome some limitations of a one-size-fits-all approach to healthcare. In research and practice, personalized medicine is being increasingly utilized. For example, it is playing an increased role in efficacy studies for biomarker-driven therapies and informs treatment.
However, for the field to evolve further, the development of highly characterized pre-clinical models is essential in order to evaluate new targeted therapies and increase the scope of actionable mutations in the clinic. One such model, which helps bridge the preclinical research and the clinic, is the patient-derived xenografts (PDX) - where tissue from a patient's tumor is implanted into an immunodeficient or humanized mouse.
Using PDX models in research means that mutations seen in the clinic can be factored into the discovery pipeline from the earliest phases of a research program, in the preclinical setting. Andrew Brown, Global Product Manager at Envigo explains how this approach could transform the future of cancer treatments:
"PDX models allow us to work backwards from the clinic, so that development phases can target the mutations seen in patients. We can then go on to screen for those mutations in other patients, offering the opportunity to pair up an individual with the treatment that's been targeted to a true representation of their tumor."+ Read more