Research models and services blog posts

25 November, 2019

Best practices for bridging studies to generate data and validate a new strain

By Travis Rothrock

In this blog on bridging studies, we provide general best-practices relevant to oncology bridging studies, including basic study design considerations and insights that are the culmination of many years of hands-on experience by Envigo experts.

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16 October, 2019

Top 3 benefits of RFID microchips for monitoring your surgical studies

By Brad Gien

Manual surgical monitoring techniques can be tedious for lab technicians as well as animals, given the multiple welfare checks needed per day plus the need for workers to update records accordingly. Further complicating matters, manual monitoring is generally done during daytime work hours, which causes researchers to miss out on valuable nighttime data points and activities. Fortunately, laboratories around the globe have a new tool at their disposal: implantable radio frequency identification (RFID) microchips. This innovative technology monitors rodents’ home cage temperature and activity, “hands-free.”

With RFID microchips, lab animals can now be monitored in a non-invasive, real-time, continuous manner, while housed either singly or in groups. In a recent five-day study, our team at Envigo collaborated with the technology company Unified Information Devices in attempt to both enhance the pre- and post-surgical monitoring of cardiac surgical models and improve animal welfare.

Six groups of rats and six groups of mice were implanted with standard RFID microchips via intraperitoneal injection. Rodents were assigned to either an MI or TAC group and housed in one cage per study group. A wealth of data was generated from this study, bringing to light the many ways RFID technology can provide for more effective animal monitoring.

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12 August, 2019

Top 4 reasons to use peer-reviewed publications to support oncology model research

By Jamie Naden

Preclinical evaluation of a molecular compound and testing a therapeutic approach for a potential cancer treatment often relies on biomedical research with cancer cell lines. Selecting the most appropriate oncology cell line to support an experimental design and drug development strategy requires careful consideration of a number of factors to ensure the research provides robust results that can translate from in vitro to in vivo and ultimately into the clinic.

Peer-reviewed publications serve as an important component of the pre-planning process to stay up-to-date on the most current literature and findings about results generated from oncology cell lines. These references help researchers compare the advantages and drawbacks of using certain preclinical oncology models, understand potential risks and make more informed decisions in selecting a cell line for their preclinical studies.   

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03 December, 2018

4 key animal research insights from AALAS 2018

By Jennifer Brooks

The 69th American Association for Laboratory Animal Science (AALAS) National Meeting recently took place in Baltimore, Maryland.  A forum for those dedicated to the humane care and treatment of laboratory animals, delegates from the academic community, research institutions, government organizations and commercial companies came together to enjoy a series of scientific lectures, poster sessions and exhibits. Delegates also received the latest industry news and insights, including updates from regulatory agencies which we’ve summarized into key take home messages.

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22 October, 2018

Top 4 reasons to choose HSD: Sprague Dawley® SD® rats for your next reproductive toxicology study

By Mandy Horn

shutterstock_132982877A new study using Hsd:Sprague Dawley® SD® rats confirms the use of this strain as a valuable toxicology model. Over the years, this strain has been used in many fields such as reproductive endocrinology, toxicology, oncology, cardiology and neuroscience.

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21 September, 2018

Diet selection 101: Making informed decisions about lab animal diets

By Luz Merle

Diet continues to be an overlooked variable in experimental investigations, impacting reproduction, growth, and disease, as well as affecting the response to experimental manipulation in laboratory animals.

Given that reproducibility is a key principle in the conduct and validation of experimental science, how can you ensure that your laboratory animal diet does not unduly influence your outcomes and conclusions drawn from your empirical data?

To answer this question, let’s discuss the function of a diet as a research tool and examine some of the key considerations in choosing the most optimal diet for your study’s needs.

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14 September, 2018

5 smart strategies to improve animal welfare

By Brad Gien

The research industry is increasingly relying on new techniques and technologies to improve animal welfare. Improvements have been limited as paper-based systems can cause issues with access and accuracy, while electronic documents face challenges with tracking and compliance. We've been focused on reducing animal usage and furthering the 3Rs – replacement, refinement and reduction, through the use of innovative technology that monitors the proficiency of surgeons and tracks surgery of models, and we'd like to share our findings with you. Learn about this system and its strategies to improve surgical performance – and animal welfare.

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20 August, 2018

5 reasons why the R2G2® mouse could help you achieve your oncology research milestones

By Jamie Naden

The R2G2® mouse has the potential to help you break new ground in investigational cancer therapies. In two recent studies, this model tolerated standard of care chemotherapy and estrogen supplementation well in terms of overall survival and changes in body weight. Here are five reasons why this mouse model could serve as an excellent host for your preclinical human tumor xenograft studies.

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16 May, 2018

3 reasons why Wistar Han® could be the perfect model for your study

By Mandy Horn

The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Our researchers recently completed a two-year study of 130 male and 130 female Envigo RccHan®:WIST (Wistar Han®) rats and compared them to other outbred rats (e.g., Sprague-Dawley®, Fischer 344). Here, we share the results of the study.

The results provided insights on how Wistar Han provided numerous advantages, such as smaller body size, higher rates of survival and lower tumor/lesion incidence, as compared to CRL:CD®(SD) (CD) rat models that were the subjects of a previous two-year study.

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09 April, 2018

How can cryopreservation safeguard vulnerable model strains?

By Luz Merle

You’ve spent years building the ideal colony for your study – and have invested even more resources into maintaining it for future usage. Imagine that after investing time and money developing and maintaining your colony, it could become redundant due to a natural disaster, microbial contamination, or facility failure. And, given the increased use of immunodeficient models and sensitive microbiota research projects, along with the cost and complexity of model breeding, cryopreservation should be woven into the fabric of each and every research project.

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