Research models and services blog posts

30 May, 2018

Joining forces to drive breakthroughs in the treatment of cancer

By Freddie Campbell

Cancer continues to be one of the main areas of focus in drug development. Unmet patient needs and advances in the understanding of cancer biology is resulting in exciting development in cancer treatments. We recently partnered with the National Foundation for Cancer Research at the American Association for Cancer Research (AACR) Annual Meeting where we explored groundbreaking advancements in cancer research and helped attendees recognize the power of their donations to build a healthier and safer world.

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16 May, 2018

3 reasons why Wistar Han® could be the perfect model for your study

By Mandy Horn

The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Our researchers recently completed a two-year study of 130 male and 130 female Envigo RccHan®:WIST (Wistar Han®) rats and compared them to other outbred rats (e.g., Sprague-Dawley®, Fischer 344). Here, we share the results of the study.

The results provided insights on how Wistar Han provided numerous advantages, such as smaller body size, higher rates of survival and lower tumor/lesion incidence, as compared to CRL:CD®(SD) (CD) rat models that were the subjects of a previous two-year study.

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09 April, 2018

How can cryopreservation safeguard vulnerable model strains?

By Luz Merle

You’ve spent years building the ideal colony for your study – and have invested even more resources into maintaining it for future usage. Imagine that after investing time and money developing and maintaining your colony, it could become redundant due to a natural disaster, microbial contamination, or facility failure. And, given the increased use of immunodeficient models and sensitive microbiota research projects, along with the cost and complexity of model breeding, cryopreservation should be woven into the fabric of each and every research project.

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05 March, 2018

4 key considerations when selecting a rodent surgical model

By Brad Gien

Animal catheterization serves a valuable tool to reduce experimental variability in several ways. It allows for consistent dosing as well as consistent blood sampling, while at the same time decreasing stress to animals and their handlers. But not all catheter types are created equally. Understanding the different options will help you select the optimal rodent surgical model for your study.

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12 January, 2018

8 insightful Envigo antibody resources from 2017

By John Kennett

Maximize your research, diagnostic or therapeutic use of antibodies in 2018 and beyond

It was a busy year for Envigo’s custom antibodies team in 2017.  As another year came to an end, we collated a round-up of the top 8 insightful materials that were published by the team throughout last year.  We hope these will help you maximize your research, diagnostic or therapeutic use of antibodies in 2018 and beyond.

Wishing you a prosperous 2018!

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21 December, 2017

Imagine a world without antibodies

By John Kennett

Ongoing efforts to advance research, diagnostics and therapeutic products

It is hard to imagine a world without antibodies. Besides their natural ability to fight off diseases in animals, they are widely used by the scientific community as research and development tools. Antibodies, both polyclonal (pAb) and monoclonal (mAb), are well established and versatile reagent tools for the study of a wide variety of biological functions, 3D structure analysis, metabolic pathways studies, in vivo imaging, cell modulation, and quantification of a host of analytes. They are also used as therapeutic drugs and are amongst the biggest selling therapeutics making a significant difference to patients’ lives.

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18 December, 2017

How do you intend to use your antibody?

By John Kennett

Antigen selection and preparation

Optimal selection and preparation of the antigen is crucial to obtaining high-quality antibodies in both polyclonal and monoclonal antibody production. Although the importance of antigen selection and preparation is not immediately apparent to some in the field, Envigo’s experience has shown that it is a critical consideration.

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23 November, 2017

Antibody reproducibility: the importance to your research

By Richard Harrison

The production of antibodies for use in research and development and in medicine has a long history. Although there is no doubt that the use of antibodies has made a significant contribution to our basic understanding of biology, they have also been singled out as a major factor in the poor reproducibility of many biology-based studies.

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22 November, 2017

Best practices for bridging studies to generate data and validate a new strain

By Travis Rothrock

In this final blog on bridging studies, we provide general best-practices relevant to oncology bridging studies, including basic study design considerations and insights that are the culmination of many years of hands-on experience by Envigo experts.

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22 November, 2017

The importance of bridging studies when switching strains

By Travis Rothrock

Bridging studies play an important role in drug development, both in the clinical and preclinical stages. These studies provide important information that can circumvent the repetition of entire programs. Understanding the considerations and steps in switching rodent strains and the importance of bridging studies, is critical. In this post we outline the best practices on bridging studies.

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