Research models and services blog posts

21 September, 2018

Diet selection 101 - Making informed decisions about lab animal diets

By Luz Merle

Diet continues to be an overlooked variable in experimental investigations, impacting reproduction, growth, and disease, as well as affecting the response to experimental manipulation in laboratory animals.

Given that reproducibility is a key principle in the conduct and validation of experimental science, how can you ensure that your laboratory animal diet does not unduly influence your outcomes and conclusions drawn from your empirical data?

To answer this question, let’s discuss the function of a diet as a research tool and examine some of the key considerations in choosing the most optimal diet for your study’s needs.

+ Read more
 

14 September, 2018

5 smart strategies to improve animal welfare

By Brad Gien

The research industry is increasingly relying on new techniques and technologies to improve animal welfare. Improvements have been limited as paper-based systems can cause issues with access and accuracy, while electronic documents face challenges with tracking and compliance. We've been focused on reducing animal usage and furthering the 3Rs – replacement, refinement and reduction, through the use of innovative technology that monitors the proficiency of surgeons and tracks surgery of models, and we'd like to share our findings with you. Learn about this system and its strategies to improve surgical performance – and animal welfare.

+ Read more
 

20 August, 2018

5 reasons why the R2G2® mouse could help you achieve your oncology research milestones

By Jamie Naden

The R2G2® mouse has the potential to help you break new ground in investigational cancer therapies. In two recent studies, this model tolerated standard of care chemotherapy and estrogen supplementation well in terms of overall survival and changes in body weight. Here are five reasons why this mouse model could serve as an excellent host for your preclinical human tumor xenograft studies.

+ Read more
 

30 May, 2018

Joining forces to drive breakthroughs in the treatment of cancer

By Freddie Campbell

Cancer continues to be one of the main areas of focus in drug development. Unmet patient needs and advances in the understanding of cancer biology is resulting in exciting development in cancer treatments. We recently partnered with the National Foundation for Cancer Research at the American Association for Cancer Research (AACR) Annual Meeting where we explored groundbreaking advancements in cancer research and helped attendees recognize the power of their donations to build a healthier and safer world.

+ Read more
 

16 May, 2018

3 reasons why Wistar Han® could be the perfect model for your study

By Mandy Horn

The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Our researchers recently completed a two-year study of 130 male and 130 female Envigo RccHan®:WIST (Wistar Han®) rats and compared them to other outbred rats (e.g., Sprague-Dawley®, Fischer 344). Here, we share the results of the study.

The results provided insights on how Wistar Han provided numerous advantages, such as smaller body size, higher rates of survival and lower tumor/lesion incidence, as compared to CRL:CD®(SD) (CD) rat models that were the subjects of a previous two-year study.

+ Read more
 

09 April, 2018

How can cryopreservation safeguard vulnerable model strains?

By Luz Merle

You’ve spent years building the ideal colony for your study – and have invested even more resources into maintaining it for future usage. Imagine that after investing time and money developing and maintaining your colony, it could become redundant due to a natural disaster, microbial contamination, or facility failure. And, given the increased use of immunodeficient models and sensitive microbiota research projects, along with the cost and complexity of model breeding, cryopreservation should be woven into the fabric of each and every research project.

+ Read more
 

05 March, 2018

4 key considerations when selecting a rodent surgical model

By Brad Gien

Animal catheterization serves a valuable tool to reduce experimental variability in several ways. It allows for consistent dosing as well as consistent blood sampling, while at the same time decreasing stress to animals and their handlers. But not all catheter types are created equally. Understanding the different options will help you select the optimal rodent surgical model for your study.

+ Read more
 

12 January, 2018

8 insightful Envigo antibody resources from 2017

By John Kennett

Maximize your research, diagnostic or therapeutic use of antibodies in 2018 and beyond

It was a busy year for Envigo’s custom antibodies team in 2017.  As another year came to an end, we collated a round-up of the top 8 insightful materials that were published by the team throughout last year.  We hope these will help you maximize your research, diagnostic or therapeutic use of antibodies in 2018 and beyond.

Wishing you a prosperous 2018!

+ Read more
 

21 December, 2017

Imagine a world without antibodies

By John Kennett

Ongoing efforts to advance research, diagnostics and therapeutic products

It is hard to imagine a world without antibodies. Besides their natural ability to fight off diseases in animals, they are widely used by the scientific community as research and development tools. Antibodies, both polyclonal (pAb) and monoclonal (mAb), are well established and versatile reagent tools for the study of a wide variety of biological functions, 3D structure analysis, metabolic pathways studies, in vivo imaging, cell modulation, and quantification of a host of analytes. They are also used as therapeutic drugs and are amongst the biggest selling therapeutics making a significant difference to patients’ lives.

+ Read more
 

18 December, 2017

How do you intend to use your antibody?

By John Kennett

Antigen selection and preparation

Optimal selection and preparation of the antigen is crucial to obtaining high-quality antibodies in both polyclonal and monoclonal antibody production. Although the importance of antigen selection and preparation is not immediately apparent to some in the field, Envigo’s experience has shown that it is a critical consideration.

+ Read more