Research models and services blog posts

16 May, 2018

3 reasons why Wistar Han® could be the perfect model for your study

By Mandy Horn

The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Our researchers recently completed a two-year study of 130 male and 130 female Envigo RccHan®:WIST (Wistar Han®) rats and compared them to other outbred rats (e.g., Sprague-Dawley®, Fischer 344). Here, we share the results of the study.

The results provided insights on how Wistar Han provided numerous advantages, such as smaller body size, higher rates of survival and lower tumor/lesion incidence, as compared to CRL:CD®(SD) (CD) rat models that were the subjects of a previous two-year study.

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09 April, 2018

How can cryopreservation safeguard vulnerable model strains?

By Luz Merle

You’ve spent years building the ideal colony for your study – and have invested even more resources into maintaining it for future usage. Imagine that after investing time and money developing and maintaining your colony, it could become redundant due to a natural disaster, microbial contamination, or facility failure. And, given the increased use of immunodeficient models and sensitive microbiota research projects, along with the cost and complexity of model breeding, cryopreservation should be woven into the fabric of each and every research project.

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05 March, 2018

4 key considerations when selecting a rodent surgical model

By Brad Gien

Animal catheterization serves a valuable tool to reduce experimental variability in several ways. It allows for consistent dosing as well as consistent blood sampling, while at the same time decreasing stress to animals and their handlers. But not all catheter types are created equally. Understanding the different options will help you select the optimal rodent surgical model for your study.

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12 January, 2018

8 insightful Envigo antibody resources from 2017

By John Kennett

Maximize your research, diagnostic or therapeutic use of antibodies in 2018 and beyond

It was a busy year for Envigo’s custom antibodies team in 2017.  As another year came to an end, we collated a round-up of the top 8 insightful materials that were published by the team throughout last year.  We hope these will help you maximize your research, diagnostic or therapeutic use of antibodies in 2018 and beyond.

Wishing you a prosperous 2018!

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21 December, 2017

Imagine a world without antibodies

By John Kennett

Ongoing efforts to advance research, diagnostics and therapeutic products

It is hard to imagine a world without antibodies. Besides their natural ability to fight off diseases in animals, they are widely used by the scientific community as research and development tools. Antibodies, both polyclonal (pAb) and monoclonal (mAb), are well established and versatile reagent tools for the study of a wide variety of biological functions, 3D structure analysis, metabolic pathways studies, in vivo imaging, cell modulation, and quantification of a host of analytes. They are also used as therapeutic drugs and are amongst the biggest selling therapeutics making a significant difference to patients’ lives.

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18 December, 2017

How do you intend to use your antibody?

By John Kennett

Antigen selection and preparation

Optimal selection and preparation of the antigen is crucial to obtaining high-quality antibodies in both polyclonal and monoclonal antibody production. Although the importance of antigen selection and preparation is not immediately apparent to some in the field, Envigo’s experience has shown that it is a critical consideration.

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23 November, 2017

Antibody reproducibility: the importance to your research

By Richard Harrison

The production of antibodies for use in research and development and in medicine has a long history. Although there is no doubt that the use of antibodies has made a significant contribution to our basic understanding of biology, they have also been singled out as a major factor in the poor reproducibility of many biology-based studies.

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22 November, 2017

Bridging studies - Why do researchers switch rodent strains?

By Travis Rothrock

Selecting the right model and rodent strain for your oncology studies can maximize the chances of success. However, there is an ever-increasing portfolio of available models and strains that may perform better than existing ones and may be more optimal for specific study purposes.

Increasing investigators are seeking to bridge from an existing rodent strain to another for their oncology preclinical efficacy and pharmacology studies. The short-term barriers associated with switching strains can appear complex and daunting, but another strain may actually be the key to the success of your oncology preclinical program.

Be sure to understand how you can benefit from switching to a new oncology rodent strain.

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22 August, 2017

5 easy ways to avoid antibody production mistakes

By Richard Drucker

Creating highly productive cell lines requires a great level of care that starts with cell line development. Envigo’s Rook Khajenouri and Richard Drucker understand the challenges customers face throughout the process. They recently discussed some common production problems and offered solutions for ensuring consistent and reliable results that enhanced antibody production.

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13 July, 2017

5 Tips to successful monoclonal antibody production

By Richard Harrison

Monoclonal antibodies play a critical role in research, diagnostics and product development and provide numerous benefits to patients in diverse therapeutic areas.

mAbs are capable of recognizing only one epitope found on an antigen. Therefore they have greater specificity than polyclonal antibodies (pAbs), which makes them ideal for diagnostic and therapeutic uses. Custom monoclonal antibody production requires a different skillset than polyclonal antibody production, and often results in additional costs and time.

The specificity of mAbs has made them ideal for medical applications such as diagnostic and therapeutic use. So what are the key considerations in the production of monoclonal antibodies?

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