The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, with ~24% of the US and European populations estimated to be affected. NAFLD is defined as the presence of fat in liver parenchyma without inflammation, but in the absence of excess alcohol consumption. In many NAFLD cases, a more aggressive form of fatty liver disease develops: Nonalcoholic steatohepatitis (NASH). NASH is associated with liver inflammation, and there is potential for extensive fibrosis to develop, leading eventually to cirrhosis. NAFLD and NASH are therefore increasingly important public health concerns, yet treatment options remain limited.
Although lifestyle management can be effective in bringing NAFLD and NASH under control, it is very difficult to implement and maintain in practice. Therefore, there is an urgent need to develop a deeper understanding of the disease and how it progresses, and to provide additional treatment solutions. Animal models developed through diet manipulation are critically important for achieving these aims. At Envigo, we have a number of diet options available to NAFLD/NASH researchers. Our nutritionists are also available to assist researchers in identifying the diet that best fits their specific research goal.+ Read more